Abstract P-219

P 219 Distribution of integrins in the rabbit lens epithelium

Purpose : Cell-~11 and cell-subsbatum interactions are mediated through different families of receptors in particular integrins. These cell receptors influence many physiological processes including cellular pmlifemtion and differentiation which are implicated in the secondzuy cataract development. The current study reports the distribution of the integrins expressed at the cell surface in a no...

Lecture Notes for Ph 219 / CS 219 : Quantum Information

Dev126326 219..231

Notch signalling is involved in a multitude of developmental decisions and its aberrant activation is linked to many diseases, including cancers. One example is the neural stem cell tumours that arise from constitutive Notch activity in Drosophila neuroblasts. To investigate how hyperactivation of Notch in larval neuroblasts leads to tumours, we combined results from profiling the upregulated m...

Dmd067868 209..219

The thiouracil derivative PF-06282999 [2-(6-(5-chloro-2-methoxyphenyl)4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide] is an irreversible inactivator of myeloperoxidase and is currently in clinical trials for the potential treatment of cardiovascular diseases. Concerns over idiosyncratic toxicity arising from bioactivation of the thiouracil motif to reactive species in the liver have bee...

C1lc20678h 219..226

In this work, we developed a microfluidic device for the imitation of drug metabolism in human liver and its cytotoxicity on cells. The integrated microfluidic device consists of three sections: (1) bioreactors containing poly(ethylene) glycol (PEG) hydrogel encapsulated human liver microsomes (HLMs); (2) cell culture chambers for cytotoxicity assay; and (3) integrated micro solid-phase extract...